Neutrophil Gelatinase Associated Lipocalin Detection Reagent(NGAL)(Immunofluorescence Chromatography)
NGAL overview
Neutrophil gelatinase-associated lipocalin (NGAL) is a small molecule protein expressed in neutrophils. NGAL is expressed in renal tubular epithelial cells in large quantities within 2 hours of acute kidney injury and released into urine and blood. , And obviously increase when combined with sepsis, with the characteristics of rapid response, high specificity, and little influence by other factors. Therefore, it is used as an early sensitive biomarker of acute kidney injury, and it can also play a predictive role in the diagnosis of sepsis. High concentrations of NGAL can be detected in the urine and blood of patients with chronic kidney disease caused by many diseases, so it is also used for the diagnosis and monitoring of chronic kidney disease.
NGAL performance index
| Detection range | sample size | Sample type | Test time |
| 50~5000ng/mL | 10μl | Whole blood / serum / plasma / urine | 10min |
Main functions of NGAL
NGAL has a powerful function, in addition to binding and transporting hydrophobic small molecules as a member of the apolipoprotein family, it is also related to inflammation, embryonic development, immune response, chemotaxis, signal transduction and the occurrence and development of a variety of tumors.
NGAL can promote the differentiation of renal progenitor cells into early tubular epithelial cells, repair N-cadherin, up regulate heme oxygenase and inhibit cell death.
Clinical significance of NGAL
- Diagnostic early warning of chronic kidney disease and secondary kidney disease
- Evaluation of tissue specificity in tumor diseases
- It is related to the occurrence and development of cardiovascular disease
- Effective markers for early diabetic nephropathy
Application Department
Nephrology, surgery, oncology, ICU, pediatrics, cardiology, endocrinology, Urology, etc
Clinical comparison of NGAL
Company profile
Zhongxiu Science And Technology Co.,Ltd., is a high-tech enterprise engaged in the research and development, production and operation of in vitro diagnostic products. The in vitro diagnostic products developed by the company cover POCT series, microbial series, biochemical series and immune series reagents and supporting instruments.
The company has always adhered to the core concept of "fast and accurate, living up to life", committed to providing society with excellent products and services, and contributing to the cause of human health.
