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Luteinizing hormone is a glycoprotein gonadotropin secreted by basophils in the anterior pituitary gland. It is mainly used to promote ovulation. Under the synergistic effect of FSH, it forms the corpus luteum and secretes progesterone. Generally, the normal value during the non-ovulatory period is 5~25mIU/ml, lower than 5mIU/ml indicates insufficient gonadotropin function, which is seen in Sheehan's syndrome. High FSH and high LH indicate ovarian function decline, LH/FSH≥ 3 is one of the basis for the diagnosis of polycystic ovary syndrome.
Detection range | sample size | Sample type | Test time |
0.2~160mIU/mL | 60μl | Whole blood / serum / plasma | 15min |
Corresponding items | index | Guiding significance | |
FSH,LH | ↑ | Common in primary gonadal lesions | Such as premature ovarian failure, hypogonadism, primary amenorrhea, primary sexual dysfunction, dysplasia of seminiferous tubules, complete (true) precocious puberty |
↓ | Mainly seen in pituitary or hypothalamic amenorrhea, incomplete (pseudo) precocious puberty. | ||
Pituitary FSH tumor or LH tumor | Due to different tumor types, FSH and LH concentrations show different types of changes | FSH tumors are mainly manifested as increased FSH, but LH can be normal; for LH tumors, LH is significantly increased, and FSH is decreased | For FSH/LH tumors, both FSH and LH are increased |
Concentration of FSH and LH in amenorrhea women | Effectively distinguish ovarian amenorrhea from pituitary or hypothalamic amenorrhea |
Gynecology, obstetrics, laboratory, oncology, reproductive medicine, genetics, etc
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