B-Type Natriuretic Peptide Detection Reagent(BNP)(Immunofluorescence Chromatography) Clinical Significance
BNP Overview
BNP is mainly synthesized and secreted by ventricular myocytes, and the changes of ventricular load and wall tension are the main conditions to stimulate BNP secretion. BNP can promote the excretion and urination of sodium, has a strong vasodilation effect. B-type natriuretic peptide is significantly increased in patients with atrial fibrillation and heart failure. BNP is one of the most common biomarkers of heart failure in clinical application.
There are two ways to clear BNP: one is mediated by the C-type receptor of the natriuretic peptide family, which is degraded by lysosomes after being endocytosed into the cell; the other is degradation by neutral endopeptidase (NEP).
BNP performance index
| Detection range | sample size | Sample type | Test time |
| 5～5000pg/mL | 60μl | Plasma / whole blood | 15min |
BNP Clinical Significance
- Differential diagnosis and risk stratification in patients with early heart failure
- Evaluation of the severity of heart failure.
- Risk stratification of acute coronary heart disease.
- Differentiation of different causes of heart failure and dyspnea
- Drug efficacy monitoring
| BNP | Suggestions for clinical application |
| <100pg/mL | HF is very unlikely |
| 100-400pg/mL | Heart failure is low and can be diagnosed with other clinical symptoms. |
| ＞400pg/mL | HF is likely |
Application Department
Cardiology, emergency department, Nephrology, respiratory medicine, etc
BNP Clinical comparison
Company profile
Zhongxiu Science And Technology Co.,Ltd., is a high-tech enterprise engaged in the research and development, production and operation of in vitro diagnostic products. The in vitro diagnostic products developed by the company cover POCT series, microbial series, biochemical series and immune series reagents and supporting instruments.
The company has always adhered to the core concept of "fast and accurate, living up to life", committed to providing society with excellent products and services, and contributing to the cause of human health.
